Treatment for osteoporosis includes
abating the rate of bone loss or expanding the rate of bone arrangement. There
are two kinds of meds for this.
• Drugs that moderate the rate of
bone misfortune are called antiresorptive meds.
• Ones that expansion the rate of
bone development is called anabolic meds.
Antiresorptive Medications
These medications lessen bone
misfortune by authoritative to the bone and keeping ordinary bone cells from
reabsorbing bone. They include:
• Bisphosphonates. These are
the most widely recognized treatment for osteoporosis. They can stop
bone misfortune and help lessen the danger of cracks by up to 50 percent.
They're not hormones, so ladies who can't take estrogen can utilize them.
Bisphosphonates affirmed for the treatment and counteractive action of
postmenopausal osteoporosis incorporate alendronate (Binosto, Fosamax),
ibandronate (Boniva), risedronate (Actonel) and zoledronic corrosive (Reclast).
• Denosumab. This medication
is endorsed for postmenopausal osteoporosis. It is injected under the skin at
regular intervals at a specialist's office.
• Calcitonin. This is a
normally happening hormone that diminishes bone breakdown. It is FDA-endorsed
for osteoporosis treatment yet not avoidance. It seems more fragile than
bisphosphonate drugs in avoiding breaks. Calcitonin controls the bone breakdown
and may straightforwardness torment in individuals with spine cracks. It's
accessible as a nasal shower (Miacalcin, Fortical).
• Selective estrogen receptor
modulators (SERMs). These medications work like estrogen, yet with fewer
symptoms. Raloxifene (Evista) is an FDA-endorsed SERM for the treatment and
avoidance of postmenopausal osteoporosis. It can avert bone misfortune,
particularly in the spine and hip. Studies have indicated it diminishes the
rate of spine breaks. It likewise delivers little increments in bone mass and
can bring down the danger of bosom malignant growth. In 2013, the FDA affirmed
Duavee, a mix item containing the SERM bazedoxifene and conjugated estrogens
for menopausal indications and osteoporosis.
As of not long ago, estrogen hormone
substitution treatment (HRT) was the customary method to treat menopausal side
effects and furthermore forestall osteoporosis. In any case, ongoing proof
proposes estrogen can expand the danger of bosom disease, strokes and heart
assaults. Along these lines, estrogen supplementation after menopause is
generally not used to forestall osteoporosis.
Anabolic Medications
Teriparatide (Forteo) and
abaloparatide (Tymlos) is anabolic medications affirmed to treat men and
postmenopausal ladies who have serious osteoporosis with a high danger of
cracks. These man-caused variants of parathyroid hormone to have been appeared
to animate new bone development, decline the danger of spinal breaks and
improve bone thickness. Each is given as an everyday injection for as long as
two years.
Romosozumab (Evenity), the most as
of late endorsed prescription, works by blocking sclerostin – a protein that
prevents bone from framing. It's given by injection once per month for a year
(following a year, it loses its viability). It's affirmed for postmenopausal
ladies who have had breaks, are at high hazard for them or haven't reacted to
different medications. The medication accompanies an FDA cautioning for an
expanded danger of heart assault, stroke, and cardiovascular demise.
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